Dr. Coles is a founding investor and the chairman and chief executive officer of Yumanity Therapeutics.
Previously, Dr. Coles was chairman and chief executive officer of Onyx Pharmaceuticals, Inc., which was acquired by Amgen in late 2013. Under his leadership, Onyx introduced two new innovative cancer medicines to patients and established the company’s international presence outside of the U.S. Prior to joining Onyx in 2008, he was president, chief executive officer and a member of the board of directors of NPS Pharmaceuticals, Inc. Before joining NPS Pharmaceuticals in 2005, Dr. Coles was senior vice president of commercial operations at Vertex Pharmaceuticals Inc., and earlier, held a number of executive positions at Bristol- Myers Squibb Company and positions of increasing responsibility at Merck & Co., Inc.
Educated at Johns Hopkins University, he earned a medical degree from Duke University and a master’s degree in public health from Harvard University. He completed his cardiology and internal medicine training at Massachusetts General Hospital and was a research fellow at Harvard Medical School.
Dr. Coles currently serves on the board of directors of McKesson Corporation (NYSE: MCK) and Regeneron (NASDAQ: REGN) and is a member of the board of trustees for Johns Hopkins University and Johns Hopkins Medicine. Dr. Coles is also a member of the Council for the Smithsonian’s National Museum of African American History and Culture in Washington, D.C.; a member of the board of trustees for The Metropolitan Museum of Art in New York City; a member of the board of directors of the Council on Foreign Relations, an independent, nonpartisan membership organization, think tank, and publisher; and a member on the Harvard Medical School Advisory Board.
Mr. Mohsen is chief business officer of Yumanity Therapeutics. Prior to Yumanity, Mr. Mohsen served as country manager in Canada at Cubist Pharmaceuticals (acquired by Merck), where he led the company’s first international operation from conceptualization through commercialization. In this role, he oversaw the launch of DIFICID (fidaxomicin) and approval of SIVEXTRO (tedizolid) in Canada and led the company’s commercial, scientific and administrative functions. Prior to that, Mr. Mohsen was vice president, strategy and business operations for Optimer Pharmaceuticals, which was acquired by Cubist, and helped establish the commercial infrastructure and led U.S. launch preparedness for DIFICID. Prior to Cubist, Mr. Mohsen held strategic and operational roles of increasing responsibility at Pfizer from 1997 to 2011, including vice president of strategy and vice president, multi-channel management.
Mr. Mohsen holds a B.S. in chemical engineering from Brown University, an M.S. in chemical engineering from the Massachusetts Institute of Technology and an M.B.A. from Harvard Business School.
Dr. Rhodes is chief scientific officer of Yumanity Therapeutics. Prior to Yumanity, Dr. Rhodes served as vice president, neurology discovery at Biogen, where he led a scientific organization focused on discovery and early development of novel protein and small molecule drugs for the treatment of neurodegenerative diseases. During his tenure at Biogen Idec, Dr. Rhodes’ team delivered nine new chemical entities into preclinical development in areas such as multiple sclerosis (MS), Parkinson’s disease and Alzheimer’s disease. In the Alzheimer’s disease area, Dr. Rhodes and his team played a major role in the preclinical development of BIIB037 (aducanumab), a fully human monoclonal antibody will enter Phase 3 trials later this year. In addition to drug discovery activities, Dr. Rhodes and his team led preclinical research studies in the area of translational biomarkers, played an active role in business development to grow the Biogen discovery pipeline and published seminal research findings characterizing the mechanisms of action of Tecfidera, Biogen Idec’s blockbuster oral therapy for the treatment of relapsing forms of MS.
Prior to joining Biogen Idec, Dr. Rhodes spent a combined 15 years as a discovery research leader at Johnson & Johnson Pharmaceutical Research and Development, LLC (now Janssen), and at Wyeth, where he pursued innovative approaches to the identification of novel ion channel modulators for the treatment of central nervous system diseases.
Dr. Rhodes earned his Ph.D. in anatomy and neurobiology at Boston University and completed postdoctoral training in systems neuroscience at the National Eye Institute, National Institutes of Health.
Bertrand Le Bourdonnec, Ph.D. joined Yumanity Therapeutics in July 2015 as vice president, medicinal chemistry & program management. Prior to Yumanity, Dr. Le Bourdonnec served as vice president discovery chemistry & pharmaceutical research at Cubist Pharmaceuticals, where he led a team of chemists dedicated to the discovery of novel antibacterial and human disease therapeutics. Dr. Le Bourdonnec’s industry experience spans across all stages of research and clinical development, and multiple therapeutic areas including CNS, pain, GI disorders, and infectious disease.
Dr. Le Bourdonnec joined the biopharmaceutical industry in 2000 at Adolor Corporation and held positions of increasing responsibility in the discovery group. After eight years working as a medicinal chemist and discovery program leader, advancing several new molecules into the clinic, he transitioned into development where he led multiple Adolor clinical programs. Following Adolor’s acquisition by Cubist Pharmaceuticals, Dr. Le Bourdonnec joined Cubist’s development group as program leader & senior director, and ultimately moved into his most recent role as vice president discovery chemistry & pharmaceutical research.
Dr. Le Bourdonnec received his chemical engineering degree from the Ecole Nationale Supèrieure de Chimie de Lille (France), his Ph.D. in organic chemistry and a masters degree in drug design from the Institut de Chimie Pharmaceutique de Lille (France). Dr. Le Bourdonnec moved to the United States in 1997, to conduct a post-doctoral fellowship at the University of Minnesota, where he worked, under the supervision of Professor Philip S. Portoghese, distinguished Professor of Medicinal Chemistry, in the design and synthesis of affinity labels for the opioid receptors.
Dr. Le Bourdonnec is co-author of 32 peer-reviewed articles and is listed as an inventor in over 70 worldwide patent applications and 23 issued U.S. patents.
Dr. Robert Scannevin joined Yumanity Therapeutics in April of 2016 as vice president, discovery biology. Dr. Scannevin’s career spans more than 17 years in drug discovery research focused on the development of novel therapeutics and approaches for the treatment of neurodegenerative diseases. Prior to Yumanity, he worked at Biogen, where he served in various positions of increasing responsibility culminating as a senior director in Neurology Discovery. Prior to Biogen, Dr. Scannevin led research initiatives at Wyeth (now Pfizer) and Johnson & Johnson Pharmaceutical Research and Development (now Janssen).
In his time at Biogen, Dr. Scannevin’s laboratory focused on developing disease modifying therapies for the treatment of multiple sclerosis, amyotrophic lateral sclerosis (ALS), Parkinson’s and Alzheimer’s diseases. Dr. Scannevin led discovery programs in Alzheimer’s disease and played a significant role in the preclinical development of BIIB037 (aducanumab), which is currently in phase III clinical trials. In addition, Dr. Scannevin made key contributions to several other discovery programs that have transitioned into clinical development and was heavily involved in the development of dimethyl fumarate (Tecfidera), in which he led preclinical research activity focused on elucidating the mechanism of action of this first-in-class oral therapy. Dr. Scannevin is a recognized leader in the field of fumarate biology.
Prior to starting a research career in industry, Dr. Scannevin earned his Ph.D. at SUNY Stony Brook in the laboratory of Dr. James S. Trimmer, and received postdoctoral training at the Johns Hopkins University School of Medicine in the laboratory of Dr. Richard Huganir. He is a co-author on more than 40 peer-reviewed research articles and an inventor on several patent applications and issued patents.
Ms. Epstein is vice president, finance of Yumanity Therapeutics. Prior to Yumanity, Ms. Epstein served as chief accounting officer of Turbonomic, one of the fastest-growing companies in the virtualization and cloud management industry. In that role, she was responsible for the global finance and accounting functions, including controllership, tax, treasury, financial systems and controls. Prior to joining Turbonomic, Ms. Epstein was chief financial officer of Plastiq, an online payment solution provider. Prior to Plastiq, Ms. Epstein held senior financial roles of increasing responsibility at several fast-growing technology companies in the greater Boston area.
Ms. Epstein holds a B.A. in Psychology from Harvard College and an M.S./MBA in Accounting from Northeastern University’s D’Amore-McKim School of Business. She has held an active CPA license in Massachusetts for over twenty years. In 1993, she won the Gold Medal in Massachusetts on the CPA exam.