Careers

Careers

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. We are passionate in our commitment to bring innovation to an area of critical global medical need and create a positive impact on the lives of patients with neurodegenerative diseases.

If you would like to be considered for a position at Yumanity Therapeutics, please submit your CV with the title of the position in the subject line to careers@yumanity.com.

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Even though an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

 Position Overview:

Yumanity Therapeutics is seeking a research associate to join our interdisciplinary team and help advance our novel drug discovery programs. This position will be laboratory based and requires experience in basic molecular biology, microbiology, and sterile laboratory technique. This position will collaborate across Yumanity’s core platforms, including yeast genetic and small molecule screening, target identification and chemistry.

Responsibilities include:

  • Using genetic techniques to identify proteins that modify the toxicity of neurodegenerative disease-linked proteins in yeast.
  • Applying biochemical and genetic approaches to identify the protein targets of small molecules identified from yeast phenotypic screens.
  • Developing and performing quantitative assays for use in optimization of screening hits, including growth-based assays, reporter assays, western blotting, ELISA, and other methods.
  • Working independently with guidance once or twice daily and delivering analyzed data in a timely matter.

Experience and skills required:

  • A., B.S. or M.S. with a degree in biology or a related field.
  • >6 months laboratory experience in cell biology or biochemistry (including working or research in an academic or industrial laboratory, not including academic laboratory classes).
  • Proficiency in basic laboratory techniques and principles of cell and molecular biology.
  • Ability to organize large datasets and keep up with meticulous data recording.
  • Basic data analysis in Microsoft Excel.
  • Openness and ability to work productively in a team environment, learn new methodologies, and adapt to changing experimental approaches.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Even though an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

 Position Overview:

The systems chemical biologist will work as an integral part of the target identification team, which uses large-scale forward and reverse genetic approaches to reveal the cellular targets of compounds discovered from phenotypic screens. The position reports to the target identification team lead, and will interact across all Yumanity’s core platforms, including chemistry, yeast screening, and mammalian validation. The successful candidate will become a key individual contributor in a dynamic and multidisciplinary environment. They will demonstrate a respect for others and be highly effective in a team.

Responsibilities:

  • Independently work to predict and identify disease modifying proteins and associated chemical ligands across different yeast models of human proteinopathies.
  • Leverage large-scale genetic and chemical genetic data to predict and elucidate cellular pathways and targets related to the mechanism of action for novel compounds
  • Develop and execute genetic, biochemical, and biophysical methods to validate target-ligand engagement.
  • Contribute to the development of Yumanity’s proprietary target identification pipeline.
  • Develop, implement, and extend established bioinformatic tools to analyze internal and public data sets for hypothesis generation.
  • Create new methods, reagent sets, and assays for target identification.

 Experience and skills required:

  • PhD in Chemical biology, systems biology, molecular biology, or related discipline with 2+ years of experience of independent research.
  • Demonstrated success in identification of target or mode-of-action identification of small molecules.
  • Deep understanding of systems biology, genetic networks, and molecular biology, in yeast and/or mammalian systems, as well as the associated tools.
  • Demonstrated experience in using large-scale ‘omics-level’ and high-throughput data analysis.
  • Ability to independently develop testable biological hypotheses based on large-scale data, design, and execute the relevant bench experiments.
  • Competency in either R or Python, including implementation of computational tools, pipelines, and data visualization.
  • Knowledge of early drug development and chemoinformatic tools.
  • Experience with the application of machine learning approaches to drive hypothesis generation a plus.

 

Competencies

  • Must be able to work independently to design and analyze experiments, and clearly present findings.
  • Flexibility to work with scientists with diverse expertise, and to adapt to new methodologies as needed
  • Foster teamwork and actively participate in the review of projects with colleagues throughout the company
  • Excellent written and oral communication skills

 

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Yumanity Therapeutics, Inc.

The Opportunity

We are seeking a Senior Accountant reporting directly to the Controller. This is a fantastic development opportunity for a motivated, experienced accounting professional.

About Yumanity

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the fact that an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address several illnesses with critical unmet medical needs, including Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

Responsibilities:

  • Support key areas of the monthly financial close to ensure timely and accurate reporting on general ledger and financial results.
  • Assist in the timely preparation of journal entries, supporting schedules and analysis, and reconciliations.
  • Processing and analyzing accounting/financial information, records or transactions.
  • Ensure expense allocations to cost centers and subsidiaries are accurate.
  • Updating fixed assets and depreciation schedules as needed.
  • Assist with preparation for external financial reporting, including work paper preparation for audits and tax returns.
  • Assist in the development and documentation of key processes and controls.
  • Other duties as assigned.

Requirements:

  • Must have an Accounting degree.
  • 3+ years of experience in Accounting with a publicly-traded company. Experience at a Big 4 firm preferred.
  • Advanced Excel skills.
  • Excellent analytical and strategic skills. Good business judgment and problem-solving skills.
  • Accuracy in daily work and other projects.
  • Ability to meet communicated schedules and deadlines.
  • Exposure to system implementation projects is a plus.
  • Energetic and collaborative team member able to work with the team to achieve department objectives.
  • Experience with NetSuite is a plus.
  • Experience working in a Pharmaceutical or Biotech company a plus.
  • CPA or MBA is preferred but not required.

About You

  • Tireless work ethic with demonstrated ability to work in a fast-paced, innovative biotech environment.
  • Must be tenacious, with the emotional intelligence to know when to push harder and when to look for alternative approaches.
  • Confident and self-aware with excellent interpersonal and communication skills, both written and verbal. Highly collaborative team player with demonstrated capability of quickly establishing credibility.
  • Extremely well organized and objective oriented.
  • Self-starter with a can-do mindset

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the estimated patient population of 50 million people worldwide, this remains an area of tremendous unmet medical need with no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins and the altered biology and phenotypes driving these diseases.

 

Position Overview:

Yumanity is seeking a creative, experienced, talented and versatile scientist to join our interdisciplinary team and advance novel drug discovery programs. The position will be laboratory based, and requires strong experimental skills in neurobiology, preferably with experience in assay development. The position reports to the director of discovery biology and will collaborate across all of Yumanity’s core discovery platforms, including chemistry, yeast screening and target identification.

 

Responsibilities include:

  • Develop neurodegenerative disease model systems in primary or iPSC-derived CNS cell types.
  • Develop robust assay platforms to facilitate target validation and small molecule characterization and screening assays.
  • Be an active intellectual contributor in the Discovery group. Participate in group discussions on targets, assays, project strategies and prioritization. Present and advocate for new ideas and provide regular progress updates in large and small group settings.
  • Develop collaborative working relationships across Discovery. Foster productive interactions with chemistry, yeast small molecule screening and target identification groups.

 

Experience and skills required:

  • An MSc or PhD degree in neurobiology or relevant field.
  • A minimum of 10 years’ experience working in neurobiology or relevant field.
  • Proficiency in molecular and cell biological techniques is essential.
  • Experience modeling disease processes in mammalian cells in vitro is essential.
  • Experience in developing high content imaging assays is highly desirable.
  • Background in Alzheimer’s disease and APOE biology is desirable.

 

 

 

Competencies:

  • Ability to be technically and intellectually flexible, to be open-minded and embrace new ideas. Be nimble enough to adopt new ways of thinking and deploy alternative approaches and methodologies when necessary.
  • Ability to think critically and poses excellent problem-solving skills.
  • Skilled at developing interpersonal relationships with scientists possessing diverse expertise and working as part of a team to achieve ambitious goals.
  • Excellent written, oral communication and presentation skills.
  • Fluency with current scientific and statistical software analysis packages.

 

 

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.