Careers

Careers

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. We are passionate in our commitment to bring innovation to an area of critical global medical need and create a positive impact on the lives of patients with neurodegenerative diseases.

If you would like to be considered for a position at Yumanity Therapeutics, please submit your CV with the title of the position in the subject line to careers@yumanity.com.

Position Overview:

Yumanity is seeking a talented, versatile, and enthusiastic BS/MS research associate to support its small molecule screening and target identification/validation efforts in yeast models of neurodegenerative disease. The position reports to the Associate Director (Discovery Biology) and will interact across all of Yumanity’s core platforms, including chemistry, yeast screening and target identification, and mammalian validation. The successful candidate will become a key individual contributor in a dynamic, multidisciplinary, and collaborative team driven by our mission to deliver therapies to patients suffering from neurodegenerative disease.

Responsibilities include:

  • Profile compounds in high-throughput yeast phenotypic assays to help triage screening hits, support chemical optimization, and validate drug targets.
  • Analyze and present data from compound profiling experiments and generate reports on activity.
  • Develop cellular and/or biochemical assays to support target mechanism of action studies (including growth assays, reporter assays, flow cytometry, western blot, microscopy, etc)
  • Actively participate and contribute to group discussions on compound/target prioritization and assay development.
  • Contribute as-needed research support to senior team members.
  • Perform general laboratory support activities, including responsibilities for particular equipment (e.g., upkeep, interacting with service, etc).

Experience and skills required:

  • A Bachelor’s degree with 5+ years of experience or Master’s degree with 2+ years of experience in molecular/cell/micro- biology or related discipline. Title will be commensurate with experience.
  • Experience in standard molecular biology approaches (cloning, protein analysis, etc) is required and biochemistry experience is a plus.
  • Experience in a drug development/biotechnology setting is preferred.
  • Experience with lab automation – both use and programming – is preferred.
  • Experience with assay development, yeast genetics, and microscopy are preferred.

Competencies

  • Must be able to work independently to design, execute, and analyze experiments.
  • Must be flexible in their ability adapt to new methodologies or new directions as projects dictate.
  • Must be a committed team member with a dedication to collaborate with colleagues throughout the company.
  • Excellent written and oral communication skills
  • Fluency in standard Microsoft office suite is required. Proficiency in data/statistical analysis programs, such as Spotfire and GraphPad, is a plus. Proficiency in programming languages such as R is a plus.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Position Overview:

Yumanity is seeking an associate scientist to join our interdisciplinary team to help advance our novel drug discovery programs. This position will be laboratory based and requires experimental skills in human stem cell culture, including experience differentiating patient and control-derived progenitor cells into various central nervous system cells.  This position will report to a Senior Scientist in Discovery Biology and will collaborate across all of Yumanity’s core platforms, including yeast phenotypic screening, target identification and chemistry.

Responsibilities include:

  • Maintain induced pluripotent stem cells or embryonic stem cells and differentiate them into central nervous system cell types such as neurons, astrocytes, oligodendrocytes and microglia.
  • Perform quality control measures for stem cells and differentiated cells.
  • Support characterization and assay development of differentiated central nervous system cells.
  • Interact and collaborate with yeast screening, target ID and medicinal chemistry teams to validate compound and target activities in mammalian cells.

Experience and skills required:

  • B.S. or M.S. in biology or a related field.  A minimum of 2 years’ experience working full-time in a research laboratory (academic or industry setting) is required.
  • Proficiency in basic lab techniques and principles of cell and molecular biology required.
  • Experience in stem cell techniques is essential.
  • Familiarity with neuronal culture techniques is highly desirable.
  • Highly versatile and team-based mindset with good interpersonal skills.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Position Overview:

 This lab-based chemist will be a key part of an interdisciplinary team of scientists and will be involved in the design, synthesis, purification, and characterization of novel drugs in the areas of neurodegenerative disease. In this dynamic team focused role, the qualified candidate will also be expected to manage and run the chemistry laboratory, and act as a mentor for junior chemists as needed. 

Responsibilities include:

  • Design, synthesis, purification, and characterization of novel drugs in the areas of neurodegenerative disease
  • Scientist expected to independently drive research of a portion of the medicinal chemistry project team
  • Act as a synthetic chemistry resource within the medicinal chemistry department to solve challenging synthetic problems that arise in our internal and external teams
  • Contribute to the writing and execution of patent applications
  • Work effectively with external collaborators and CROs
  • Execute with significant initiative, ingenuity, efficiency, and speed
  • Maintenance and troubleshooting of lab equipment (NMR, LCMS etc.)

Experience & Skills required:

  • BS or MS in synthetic organic chemistry with >10 years of experience in the pharmaceutical industry
  • Experience working on various drug targets and chemical scaffolds, across multiple therapeutic areas, is preferred

Level of Independence and Initiative:

  • Capable of independently designing and executing data driven experiments and tasks
  • Completely independent with regards to synthetic chemistry
  • Bi-weekly supervision appropriate for medicinal chemistry / drug discovery / managerial discussions
  • Recognizes and independently engages appropriate sources of information such as literature, colleagues, etc.
  • Seen as a synthetic chemistry leader in department, often impacts others in department through suggestions and pioneering new techniques/equipment
  • Seen as an important player in a medicinal chemistry project team, often makes important suggestions on medicinal chemistry strategy

Scientific Proficiency, Knowledge and Expertise:

  • Can compile and interpret data from a variety of sources
  • Solid understanding of multiple areas of organic chemistry
  • Knowledge of medicinal chemistry principles and drug discovery concepts (e.g. PK, biological assay types)
  • Solid understanding of basic concepts in biology; scientist expected to work closely with biologists at Yumanity

Competencies:

  • Demonstrates a sense of urgency in advancing research
  • Flexibly adapts strategy and tactics
  • Demonstrates a respect for others and is highly effective in a team
  • Fosters teamwork and actively participates in the review of projects with colleagues throughout the company
  • Ability to effectively present ideas and document concepts in writing and orally
  • Ability to think strategically to improve current processes within the chemistry department

Work Environment:

  • Standard organic chemistry lab; typical reaction scale: 20 mg – 200 g.

Physical Demands:

  • Minor lifting of intermediates, glassware and equipment
  • Standing at hood for prolonged periods of time

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.