Careers

Careers

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. We are passionate in our commitment to bring innovation to an area of critical global medical need and create a positive impact on the lives of patients with neurodegenerative diseases.

If you would like to be considered for a position at Yumanity Therapeutics, please submit your CV with the title of the position in the subject line to careers@yumanity.com.

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the estimated patient population of 50 million people worldwide, this remains an area of tremendous unmet medical need with no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins and the altered biology and phenotypes driving these diseases.

 

Position Overview:

Yumanity is seeking a creative, experienced, talented and versatile scientist to join our interdisciplinary team and advance novel drug discovery programs. The position will be laboratory based, and requires strong experimental skills in neurobiology, preferably with experience in assay development. The position reports to the director of discovery biology and will collaborate across all of Yumanity’s core discovery platforms, including chemistry, yeast screening and target identification.

 

Responsibilities include:

  • Develop neurodegenerative disease model systems in primary or iPSC-derived CNS cell types.
  • Develop robust assay platforms to facilitate target validation and small molecule characterization and screening assays.
  • Be an active intellectual contributor in the Discovery group. Participate in group discussions on targets, assays, project strategies and prioritization. Present and advocate for new ideas and provide regular progress updates in large and small group settings.
  • Develop collaborative working relationships across Discovery. Foster productive interactions with chemistry, yeast small molecule screening and target identification groups.

 

Experience and skills required:

  • An MSc or PhD degree in neurobiology or relevant field.
  • A minimum of 10 years’ experience working in neurobiology or relevant field.
  • Proficiency in molecular and cell biological techniques is essential.
  • Experience modeling disease processes in mammalian cells in vitro is essential.
  • Experience in developing high content imaging assays is highly desirable.
  • Background in Alzheimer’s disease and APOE biology is desirable.

 

 

 

Competencies:

  • Ability to be technically and intellectually flexible, to be open-minded and embrace new ideas. Be nimble enough to adopt new ways of thinking and deploy alternative approaches and methodologies when necessary.
  • Ability to think critically and poses excellent problem-solving skills.
  • Skilled at developing interpersonal relationships with scientists possessing diverse expertise and working as part of a team to achieve ambitious goals.
  • Excellent written, oral communication and presentation skills.
  • Fluency with current scientific and statistical software analysis packages.

 

 

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the estimated patient population of 50 million people worldwide, this remains an area of tremendous unmet medical need with no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins and the altered biology and phenotypes driving these diseases.

Position Overview:

Yumanity is seeking a Laboratory Assistant to join our interdisciplinary team. This position will help manage basic laboratory operations and facilitate drug discovery activities.  The primary responsibilities of this role will be supportive in managing daily, weekly and monthly tasks that are essential for efficient laboratory function. This position requires performing operational activities in the laboratory, interacting with laboratory equipment and conducting basic laboratory techniques, so candidates must be comfortable working partly in a laboratory environment.  Appropriate state and federal training will be offered for specialized requirements in managing hazardous waste disposal and shipping. This position will report to a senior leader in the Discovery Biology team and will work across the various Yumanity platform technologies to support drug discovery and development efforts. This position is being opened as a part-time role requiring approximately 20 hours per week. Daily work schedule is flexible within a 9:00 AM – 5:00 PM day, pending approval from the supervising manager.

Responsibilities include:

  • Autoclaving waste
  • Glassware collection, washing, autoclaving, restocking
  • Filling water carboys
  • Distributing packages to laboratories (some lifting required)
  • Maintaining common laboratory inventory (ordering, stocking)
  • Managing interactions with vendor for hazardous waste disposal
  • Managing shipping of packages to external sites
  • Basic reagent preparation (water-based solutions, buffers, yeast media)
  • Filling pipette tip boxes
  • Weekly instrument calibrations

Experience and skills required:

  • Applicants must be a minimum of 18 years old
  • Preferred candidates will have biological laboratory experience
  • Well-organized, independent and detail-oriented
  • Ability to meticulously follow established standard operating protocols
  • Ability to maintain accurate documentation of activities
  • Ability to work productively in a team environment

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Position Overview:

Yumanity is seeking an associate scientist to join our interdisciplinary team to help advance our novel drug discovery programs. This position will be laboratory based, requires experience in assay development using primary and/or stem cell cultures and imaging experience. This position will report to the Director of Discovery Biology and will collaborate across Yumanity’s core platforms, including yeast phenotypic screening, target identification and chemistry.

 Responsibilities include:

  • Maintain primary cell cultures and/or stem cells of central nervous system-derived cells.
  • Support characterization and assay development of neurodegenerative-disease models in central nervous system cells.
  • Assist in developing assays to validate the activity and targets of compounds retrieved from yeast screenings
  • Develop, perform and analyze assays, including, but not limited to, ELISA, qRT-PCR, transfection/transduction and high content imaging.
  • Work independently to generate, process and present high-quality data to the Mammalian team.
  • Interact and collaborate with yeast screening, target ID and medicinal chemistry teams to validate compound and target activities in mammalian cells.

 

Experience and skills required:

  • B.S. or M.S. with a degree in biology or a related field with 2-5+ years of relevant laboratory experience.
  • Proficiency in basic lab techniques and principles of cell and molecular biology required.
  • Experience in assay development techniques using primary, CNS-derived cell cultures (astrocytes, neurons etc.) is essential.
  • Microscopy experience in high content Imaging is desirable.
  • Familiarity with stem cell culture techniques is highly desirable.
  • Well-organized, detail-orientated with meticulous data recording.
  • Ability to work productively in a team environment and adapt to changing project priorities.