Careers

Careers

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. We are passionate in our commitment to bring innovation to an area of critical global medical need and create a positive impact on the lives of patients with neurodegenerative diseases.

If you would like to be considered for a position at Yumanity Therapeutics, please submit your CV with the title of the position in the subject line to careers@yumanity.com.

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the fact that an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

Position Overview:

The Director of Program & Alliance Management will drive the overall success of Yumanity’s research and development programs.  She/he will develop, in collaboration with colleagues, manager and the executive team, the roles and responsibilities of Yumanity’s program management function that will optimally address immediate and future company needs.  The individual will work collaboratively with scientific staff and program teams to plan, track and report the diverse research and development activities including discovery, preclinical safety, pharmacokinetic/drug metabolism, process chemistry, drug manufacturing, regulatory affairs, clinical development, business development, project strategy and finance.

Scope and Responsibility:

  • Manages program team(s) and is responsible for working closely with team members to manage the operational aspects of the program(s), including developing overall tactical implementation plans, fully integrated program timelines and budgets
  • Tracks and monitors key milestones and decision points, to drive delivery of project objectives
  • Interfaces and coordinates with relevant functional groups to ensure timely execution of program activities including anticipating and identifying project risks, mitigation strategies and contingencies, and supporting timely action plans for issue resolution
  • Develop, in collaboration with colleagues, manager and the executive team, the roles and responsibilities of the program management function at Yumanity
  • Represents and reports program to senior management; ensures effective communication to align program activities with corporate strategy and ensure effective program execution
  • Fosters a culture of ownership and accountability including continuous benchmarking, evaluation, recognition and process improvement
  • Focuses operations to deliver results by influencing team members beyond existing benchmarks and their own expectations
  • Partners with finance and functional leaders to develop program budget including capability and capacity needs, and monitors spend against program budgets; develops project scenario planning for decision making
  • Ensures the development and use of key project management tools, metrics and team meeting logistics and documentation, to enhance project and program delivery and information dissemination to the business
  • Ensures effective program team meetings, logistics and documentation
  • For programs that are in alliances, drives reporting and project management with collaboration partners

Education & Experience:

  • Advanced degree [BS, MS, or PhD] in scientific discipline and/or program management
  • Additional PMP certification is preferred but not required
  • Minimum of 10 years’ experience in the Pharma/Biotech industry, with a minimum 5 years of demonstrated project management experience managing cross-functional product development efforts
  • Outstanding detailed project management skills with an integrated view of business and scientific issues and demonstrated passion for developing new medicines
  • Experience managing projects across several therapeutic area and/or drug classes (small molecules, or protein therapeutics)
  • Previous experience in supervising Project managers, mentoring staff to develop their skills and ensure they remain challenged professionally

Competencies:

  • Ability to work independently and successfully in a matrix environment
  • Prioritize and manage multiple tasks simultaneously, integrate cross-functional issues and balance competing priorities effectively
  • Demonstrates a sense of urgency in advancing projects
  • Flexibly adapts strategy and tactics
  • Demonstrates a respect for others and is highly effective in a team
  • Fosters teamwork and actively participates in the review of projects with colleagues throughout the company
  • Ability to effectively present ideas and document concepts in writing and orally
  • Ability to think strategically in order to improve current processes within Yumanity
  • Demonstrate leadership skills and ability to exert influence without direct authority

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the estimated patient population of 50 million people worldwide, this remains an area of tremendous unmet medical need with no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins and the altered biology and phenotypes driving these diseases.

 Position Overview:

Yumanity is seeking a creative, experienced, talented and versatile scientist to join our interdisciplinary team to advance novel drug discovery programs. The position will be laboratory based, and requires strong experimental skills in neurobiology, preferably with experience in assay development. The position reports to the associate director of discovery biology and will collaborate across all of Yumanity’s core discovery platforms, including chemistry, yeast screening and target identification.

Responsibilities include:

  • Develop and evaluate cell line, primary neuron, and iPSC-derived neuronal models of ALS/FTLD, including TDP-43.
  • Validate genetic and small molecule targets discovered from yeast in multiple cell-based models
  • Conceptualize and develop target engagement assays to support target validation studies and enable in vivo pharmacodynamic studies
  • Actively and intellectually contribute to group discussions on assays, targets, and project strategy, including routine presentations
  • Develop collaborative working relationships across Discovery functions, including yeast screening, target identification, and chemistry.

Experience and skills required:

  • An MSc with 10+ years or PhD with 0 – 4 years post-doctoral experience in neurobiology or related field (Title will be commensurate with experience level)
  • Assay development experience in a biotechnology or pharmaceutical setting is preferred
  • Experience modeling disease processes in mammalian cells in vitro is essential, with a preference for strong microscopy skills, including experience with high content platforms
  • Experience with developing assays to evaluate small molecule activity using imaging, reporter, viability, or other endpoints is preferred
  • Knowledgebase of neurodegeneration, including ALS/FTLD is highly desirable

 Competencies

  • Ability to be technically and intellectually flexible, to be open-minded and embrace new ideas. Be nimble enough to adopt new ways of thinking and deploy alternative approaches and methodologies when necessary.
  • Ability to think critically and possess excellent problem-solving skills
  • Skilled at developing productive cross-functional relationships with scientists to achieve ambitious team goals
  • Excellent written and oral communication skills, as well as presentations.
  • Fluency with current scientific and statistical software analysis packages.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Even though an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

 Position Overview:

The systems chemical biologist will work as an integral part of the target identification team, which uses large-scale forward and reverse genetic approaches to reveal the cellular targets of compounds discovered from phenotypic screens. The position reports to the target identification team lead, and will interact across all Yumanity’s core platforms, including chemistry, yeast screening, and mammalian validation. The successful candidate will become a key individual contributor in a dynamic and multidisciplinary environment. They will demonstrate a respect for others and be highly effective in a team.

Responsibilities:

  • Independently work to predict and identify disease modifying proteins and associated chemical ligands across different yeast models of human proteinopathies.
  • Leverage large-scale genetic and chemical genetic data to predict and elucidate cellular pathways and targets related to the mechanism of action for novel compounds
  • Develop and execute genetic, biochemical, and biophysical methods to validate target-ligand engagement.
  • Contribute to the development of Yumanity’s proprietary target identification pipeline.
  • Develop, implement, and extend established bioinformatic tools to analyze internal and public data sets for hypothesis generation.
  • Create new methods, reagent sets, and assays for target identification.

 Experience and skills required:

  • PhD in Chemical biology, systems biology, molecular biology, or related discipline with 2+ years of experience of independent research.
  • Demonstrated success in identification of target or mode-of-action identification of small molecules.
  • Deep understanding of systems biology, genetic networks, and molecular biology, in yeast and/or mammalian systems, as well as the associated tools.
  • Demonstrated experience in using large-scale ‘omics-level’ and high-throughput data analysis.
  • Ability to independently develop testable biological hypotheses based on large-scale data, design, and execute the relevant bench experiments.
  • Competency in either R or Python, including implementation of computational tools, pipelines, and data visualization.
  • Knowledge of early drug development and chemoinformatic tools.
  • Experience with the application of machine learning approaches to drive hypothesis generation a plus.

 

Competencies

  • Must be able to work independently to design and analyze experiments, and clearly present findings.
  • Flexibility to work with scientists with diverse expertise, and to adapt to new methodologies as needed
  • Foster teamwork and actively participate in the review of projects with colleagues throughout the company
  • Excellent written and oral communication skills

 

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Yumanity Therapeutics, Inc.

The Opportunity

We are seeking a Senior Accountant reporting directly to the Controller. This is a fantastic development opportunity for a motivated, experienced accounting professional.

About Yumanity

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the fact that an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address several illnesses with critical unmet medical needs, including Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

Responsibilities:

  • Support key areas of the monthly financial close to ensure timely and accurate reporting on general ledger and financial results.
  • Assist in the timely preparation of journal entries, supporting schedules and analysis, and reconciliations.
  • Processing and analyzing accounting/financial information, records or transactions.
  • Ensure expense allocations to cost centers and subsidiaries are accurate.
  • Updating fixed assets and depreciation schedules as needed.
  • Assist with preparation for external financial reporting, including work paper preparation for audits and tax returns.
  • Assist in the development and documentation of key processes and controls.
  • Other duties as assigned.

Requirements:

  • Must have an Accounting degree.
  • 3+ years of experience in Accounting with a publicly-traded company. Experience at a Big 4 firm preferred.
  • Advanced Excel skills.
  • Excellent analytical and strategic skills. Good business judgment and problem-solving skills.
  • Accuracy in daily work and other projects.
  • Ability to meet communicated schedules and deadlines.
  • Exposure to system implementation projects is a plus.
  • Energetic and collaborative team member able to work with the team to achieve department objectives.
  • Experience with NetSuite is a plus.
  • Experience working in a Pharmaceutical or Biotech company a plus.
  • CPA or MBA is preferred but not required.

About You

  • Tireless work ethic with demonstrated ability to work in a fast-paced, innovative biotech environment.
  • Must be tenacious, with the emotional intelligence to know when to push harder and when to look for alternative approaches.
  • Confident and self-aware with excellent interpersonal and communication skills, both written and verbal. Highly collaborative team player with demonstrated capability of quickly establishing credibility.
  • Extremely well organized and objective oriented.
  • Self-starter with a can-do mindset

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the estimated patient population of 50 million people worldwide, this remains an area of tremendous unmet medical need with no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins and the altered biology and phenotypes driving these diseases.

 Position Overview:

Yumanity is seeking a creative, experienced, talented and versatile scientist to join our interdisciplinary team and advance novel drug discovery programs. The position will be laboratory based, and requires strong experimental skills in neurobiology, preferably with experience in assay development. The position reports to the director of discovery biology and will collaborate across all of Yumanity’s core discovery platforms, including chemistry, yeast screening and target identification.

 Responsibilities include:

  • Develop neurodegenerative disease model systems in primary or iPSC-derived CNS cell types.
  • Develop robust assay platforms to facilitate target validation and small molecule characterization and screening assays.
  • Be an active intellectual contributor in the Discovery group. Participate in group discussions on targets, assays, project strategies and prioritization. Present and advocate for new ideas and provide regular progress updates in large and small group settings.
  • Develop collaborative working relationships across Discovery. Foster productive interactions with chemistry, yeast small molecule screening and target identification groups.

Experience and skills required:

  • An MSc or PhD degree in neurobiology or relevant field.
  • A minimum of 10 years’ experience working in neurobiology or relevant field.
  • Proficiency in molecular and cell biological techniques is essential.
  • Experience modeling disease processes in mammalian cells in vitro is essential.
  • Experience in developing high content imaging assays is highly desirable.
  • Background in Alzheimer’s disease and APOE biology is desirable.

 Competencies:

  • Ability to be technically and intellectually flexible, to be open-minded and embrace new ideas. Be nimble enough to adopt new ways of thinking and deploy alternative approaches and methodologies when necessary.
  • Ability to think critically and poses excellent problem-solving skills.
  • Skilled at developing interpersonal relationships with scientists possessing diverse expertise and working as part of a team to achieve ambitious goals.
  • Excellent written, oral communication and presentation skills.
  • Fluency with current scientific and statistical software analysis packages.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.