Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. We are passionate in our commitment to bring innovation to an area of critical global medical need and create a positive impact on the lives of patients with neurodegenerative diseases.

We invite you to browse current career opportunities and job descriptions below. If you would like to be considered for a position at Yumanity Therapeutics, please submit your CV with the title of the position in the subject line to

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the fact that an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

Position Overview:
The Senior research associate will develop cell-based assays to support small molecule screening and mechanism of action assays in yeast models of neurodegenerative disease, as well as execute genetic analyses for target identification and validation. The position reports to the associate director of phenotypic screening and will interact across all of Yumanity’s core platforms, including chemistry, yeast screening and target identification, and mammalian validation. The successful candidate will become a key individual contributor in a dynamic and multidisciplinary environment. They will demonstrate a respect for others and be highly effective in a team.

Responsibilities include:

  • Develop assays in yeast to support efficacy studies in neurodegenerative disease models (including growth assays, reporter assays, FACS, western blot, microscopy, etc)
  • Test responses of small molecule compounds in newly developed and established phenotypic assays, both in low and high-throughput formats
  • Analyze and present data from compound profiling experiments and generate reports on activity
  • Identify and validate new potential drug targets using yeast genetics and phenotypic responses
  • Actively participate and contribute to group discussions on compound/target prioritization and assay development
  • Interact with chemistry and mammalian groups to coordinate assay development and compound/target prioritization
  • Contribute as-needed research support to senior team members
  • Perform general laboratory support activities, including responsibilities for particular equipment (e.g., upkeep, interacting with service, etc)

Experience and skills required:

  • A Bachelor’s or Master’s degree in molecular/cell biology or related discipline with 10+ years experience for Bachelor’s and 5+ years of experience for Master’s
  • Experience with lab automation/robotics to support high-throughput analyses is required
  • Proficiency in standard molecular biology approaches (cloning, protein analysis, etc)
  • Experience with assay development, including phenotypic as well as reporter assays
  • Experience in a drug development/biotechnology setting is preferred
  • Experience in yeast genetics is a plus
  • Microscopy experience is a plus


  • Must be able to work independently to design/execute experiments
  • Ability to be flexible, to work with scientists with diverse expertise, and to adapt to new methodologies as needed
  • Foster teamwork and actively participate in the review of projects with colleagues throughout the company
  • Excellent written and oral communication skills
  • Computer proficiencies in Microsoft office suite, GraphPad, and LIMS systems
  • Statistical understanding and analysis is necessary
  • Bioinformatics and programming capabilities a plus (R, python, etc)

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.