Careers

Careers

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. We are passionate in our commitment to bring innovation to an area of critical global medical need and create a positive impact on the lives of patients with neurodegenerative diseases.

We invite you to browse current career opportunities and job descriptions below. If you would like to be considered for a position at Yumanity Therapeutics, please submit your CV with the title of the position in the subject line to careers@yumanity.com.

Research Associate

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the fact that an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

Position Overview:

Yumanity is seeking a talented and versatile BS/MS research associate to help develop cell-based and biochemical assays to support small molecule screening and target identification/validation studies in yeast models of neurodegenerative disease. The position reports to the Associate Director of Phenotypic Screening and will interact across all of Yumanity’s core platforms, including chemistry, yeast screening and target identification, and mammalian validation. The successful candidate will become a key individual contributor in a dynamic, multidisciplinary, and collaborative team driven by our mission to deliver therapies to patients suffering from neurodegenerative disease.

Responsibilities include:

  • Develop assays in yeast to support efficacy studies in yeast neurodegenerative disease models (including growth assays, reporter assays, flow cytometry, western blot, microscopy, etc)
  • Test responses of small molecule compounds in newly developed and established phenotypic assays, both in low and high-throughput formats.
  • Analyze and present data from compound profiling experiments and generate reports on activity.
  • Identify and validate new potential drug targets using yeast genetics and phenotypic responses
  • Actively participate and contribute to group discussions on compound/target prioritization and assay development.
  • Interact with chemistry and mammalian groups to coordinate assay development and compound/target prioritization
  • Contribute as-needed research support to senior team members.
  • Perform general laboratory support activities, including responsibilities for particular equipment (e.g., upkeep, interacting with service, etc).

Experience and skills required:

  •  A Bachelor’s degree with 5+ years of experience or Master’s degree with 2+ years of experience in molecular/cell/micro- biology or related discipline.
  • Experience in a drug development/biotechnology setting, including experience with lab automation/robotics, is preferred.
  • Proficiency in standard molecular biology approaches (cloning, protein analysis, etc) is required and biochemistry experience is a plus.
  • Experience with assay development, such as phenotypic as well as reporter assays is required.
  • Experience in yeast genetics and microscopy are a plus.

 Competencies:

  • Must be able to work independently to design/execute experiments.
  • Ability to be flexible, to work with scientists with diverse expertise, and to adapt to new methodologies as needed.
  • Foster teamwork and actively participate in the review of projects with colleagues throughout the company.
  • Excellent written and oral communication skills.
  • Computer proficiencies in Microsoft office suite, GraphPad, and LIMS systems.
  • Statistical understanding and analysis is a plus.
  • Bioinformatics and programming capabilities in R is highly desirable.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

 

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the fact that an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

Position Overview:

Yumanity is seeking a talented and versatile BS/MS scientist to join our interdisciplinary team to help advance novel drug discovery programs for neurodegenerative diseases. This position will be laboratory based, and requires strong experimental skills with background in cell and molecular biology and experience in quantitative assay development. The successful candidate must be highly flexible and team-oriented. The position will report to a Principal Scientist in the Mammalian Assay Development group, and will interact across all of Yumanity’s core platforms, including yeast phenotypic screening, target identification, stem cells and chemistry.

Responsibilities include:

  • Assist in developing neurodegenerative disease models in mammalian cells; including cell lines, rodent primary neurons and iPS cell-derived neurons.
  • Assist in developing assays to validate the activity and targets of small molecules identified from yeast phenotypic screening and target identification activities.
  • Directly interact and collaborate with the medicinal chemistry team to evaluate identified and novel small molecule activity and properties.
  • Generate and maintain embryonic rodent primary neurons to assist with development of neurodegenerative disease models and assays.
  • Analyze and interpret experimental data, address methodological challenges in experimental protocols and clearly convey results to the team in oral and written fashion.
  • Maintain accurate and up to date documentation of all laboratory activities (notebooks, databases).
  • Independently operate and oversee maintenance of selected lab equipment.
  • Consult scientific literature as needed.

Experience and skills required:

  • A Bachelor’s (+5 yrs experience) or Master’s (+3 yrs experience) degree in biology or related discipline.
  • Proficiency in basic lab techniques (Mammalian cell culture, ELISA, Western Blot, rtPCR) and principles of cell biology, biochemistry or molecular biology required.
  • Proficiency in rodent embryonic brain dissection and harvesting primary neurons techniques is highly desirable.
  • Experience in assay development.
  • Knowledge of relevant scientific databases is preferred.


All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.