Careers

Careers

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. We are passionate in our commitment to bring innovation to an area of critical global medical need and create a positive impact on the lives of patients with neurodegenerative diseases.

If you would like to be considered for a position at Yumanity Therapeutics, please submit your CV with the title of the position in the subject line to careers@yumanity.com.

Senior Scientist

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the fact that an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

Position Overview:

Yumanity is seeking a creative, talented and versatile Ph.D scientist to join our interdisciplinary team to help advance our novel drug discovery programs. This position will be laboratory based, and requires strong experimental skills in neurobiology and assay development.  The scientist in this position will collaborate across all Yumanity’s core platforms, including yeast phenotypic screening, target identification and chemistry.

Responsibilities include: 

  • Developing neurodegenerative disease models in mammalian cells including cell lines, rodent primary neurons and human iPS cell-derived neurons.
  • Developing assays to validate the activity and target of the compounds derived from yeast high-throughput screening.
  • Interacting and collaborating with yeast screening, target ID and medicinal chemistry teams to validate compound and target activities in mammalian cells.

Experience and skills required:

  • Education: Ph.D. degree in neuroscience, cell biology, biochemistry, or relevant field with 2+ year of postdoctoral experience.
  • Highly desirable to have experience in modeling neurodegenerative diseases in neurons using misfolding-prone proteins such as alpha-synuclein, APOE4 and others.
  • Skills in developing and miniaturizing assays to measure cellular responses to pathologic processes.
  • Highly versatile and team-based mindset.
  • Excellent verbal, written communication and presentation skills are essential.


All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

 

Associate Scientist

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the fact that an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

Position Overview:

Yumanity is seeking a talented and versatile BS/MS scientist to join our interdisciplinary team to help advance novel drug discovery programs for neurodegenerative diseases. This position will be laboratory based, and requires strong experimental skills with background in cell and molecular biology and experience in quantitative assay development. The successful candidate must be highly flexible and team-oriented. The position will report to a Senior Scientist in the Mammalian Assay Development group, and will interact across all of Yumanity’s core platforms, including yeast phenotypic screening, target identification, stem cells and chemistry.

Responsibilities include:

  • Assist in developing neurodegenerative disease models in mammalian cells; including cell lines, rodent primary neurons and iPS cell-derived neurons.
  • Assist in developing assays to validate the activity and targets of small molecules identified from yeast phenotypic screening and target identification activities.
  • Directly interact and collaborate with the medicinal chemistry team to evaluate identified and novel small molecule activity and properties.
  • Generate and maintain embryonic rodent primary neurons to assist with development of neurodegenerative disease models and assays.
  • Analyze and interpret experimental data, address methodological challenges in experimental protocols and clearly convey results to the team in oral and written fashion.
  • Maintain accurate and up to date documentation of all laboratory activities (notebooks, databases).
  • Independently operate and oversee maintenance of selected lab equipment.
  • Consult scientific literature as needed.


Experience and skills required:

  • A Bachelor’s (+5 yrs experience) or Master’s (+3 yrs experience) degree in biology or related discipline.
  • Proficiency in basic lab techniques (Mammalian cell culture, ELISA, Western Blot, rtPCR) and principles of cell biology, biochemistry or molecular biology required.
  • Proficiency in rodent embryonic brain dissection and harvesting primary neurons techniques is highly desirable.
  • Experience in assay development.
  • Knowledge of relevant scientific databases is preferred.


All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.