Careers

Careers

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. We are passionate in our commitment to bring innovation to an area of critical global medical need and create a positive impact on the lives of patients with neurodegenerative diseases.

If you would like to be considered for a position at Yumanity Therapeutics, please submit your CV with the title of the position in the subject line to careers@yumanity.com.

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the fact that an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

Position Overview:

Yumanity is seeking an associate scientist to join our interdisciplinary team to help advance our novel drug discovery programs. This position will be laboratory based and requires experimental skills in cell biology and assay development.  This position will report to a Senior Scientist in Discovery Biology and will collaborate across all of Yumanity’s core platforms, including yeast phenotypic screening, target identification and chemistry.

 Responsibilities include:

  • Assisting in developing neurodegenerative disease models in mammalian cells including cell lines, rodent primary neurons and iPS cell-derived neurons.
  • Assisting in develop assays to validate the activity and target of the compounds retrieved from yeast screening.
  • Interacting and collaborating with yeast screening and target ID team to validate the compounds and targets in mammalian cells.
  • Interacting and collaborating with the medicinal chemistry team to improve the compound properties and activities.

Experience and skills required:

  • B.S. or M.S. in biology or a related field.  A minimum of 2 years’ experience working full-time in a research laboratory (academic or industry setting) is required.
  • Proficiency in basic lab techniques and principles of cell and molecular biology required.
  • Experience in cell culture and imaging techniques is essential.
  • Familiarity with neuronal culture techniques is highly desirable.
  • Highly versatile and team-based mindset with good interpersonal skills.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Despite the estimated patient population of 50 million people worldwide, this remains an area of tremendous unmet medical need with no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins and the altered biology and phenotypes driving these diseases.

 Position Overview:

Yumanity is seeking a creative, experienced, talented and versatile scientist to join our interdisciplinary team to advance novel drug discovery programs. The position will be laboratory based, and requires strong experimental skills in neurobiology, preferably with experience in assay development. The position reports to the associate director of discovery biology and will collaborate across all of Yumanity’s core discovery platforms, including chemistry, yeast screening and target identification.

Responsibilities include:

  • Develop and evaluate cell line, primary neuron, and iPSC-derived neuronal models of ALS/FTLD, including TDP-43.
  • Validate genetic and small molecule targets discovered from yeast in multiple cell-based models
  • Conceptualize and develop target engagement assays to support target validation studies and enable in vivo pharmacodynamic studies
  • Actively and intellectually contribute to group discussions on assays, targets, and project strategy, including routine presentations
  • Develop collaborative working relationships across Discovery functions, including yeast screening, target identification, and chemistry.

Experience and skills required:

  • An MSc with 10+ years or PhD with 0 – 4 years post-doctoral experience in neurobiology or related field (Title will be commensurate with experience level)
  • Assay development experience in a biotechnology or pharmaceutical setting is preferred
  • Experience modeling disease processes in mammalian cells in vitro is essential, with a preference for strong microscopy skills, including experience with high content platforms
  • Experience with developing assays to evaluate small molecule activity using imaging, reporter, viability, or other endpoints is preferred
  • Knowledgebase of neurodegeneration, including ALS/FTLD is highly desirable

 Competencies

  • Ability to be technically and intellectually flexible, to be open-minded and embrace new ideas. Be nimble enough to adopt new ways of thinking and deploy alternative approaches and methodologies when necessary.
  • Ability to think critically and possess excellent problem-solving skills
  • Skilled at developing productive cross-functional relationships with scientists to achieve ambitious team goals
  • Excellent written and oral communication skills, as well as presentations.
  • Fluency with current scientific and statistical software analysis packages.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.